Further evidence for Clock 19 mice as a model for bipolar disorder ...
In the present studies of Clock 19 and wildtype (WT) littermate mice, we quantified exploratory behavior and sensorimotor gating, which are abnormal in BD manic patients. We also …
008169 - Tau P301S (PS19) Strain Details - The Jackson Laboratory
These PS19 transgenic mice (P301S Tg mice) express the P301S mutant form of human microtubule-associated protein tau (MAPT), under the direction of the mouse prion protein …
The Clock Mechanism Influences Neurobiology and Adaptations …
We demonstrate that Clock∆19/∆19 mice have neurons with smaller apical dendrite trees within layer 2/3 of the medial prefrontal cortex (mPFC) and CA1 region of the hippocampus, and …
A mutation in CLOCK leads to altered dopamine receptor function
Mice with a mutation in the Clock gene (Clock Δ19) have a number of behavioral phenotypes that suggest alterations in dopaminergic transmission. These include hyperactivity, increased …
CLOCKΔ19 mutation modifies the manner of synchrony among
Jan 16, 2018 · In the SCN, CLOCK works as an essential component of molecular circadian oscillation, and Clock Δ19 mutant mice show unique characteristics of circadian rhythms such …
Further evidence for ClockΔ19 mice as a model for bipolar …
Jul 15, 2013 · In the present studies of Clock Δ19 and wildtype (WT) littermate mice, we quantified exploratory behavior and sensorimotor gating, which are abnormal in BD manic …
Disrupting the key circadian regulator CLOCK leads to age …
Apr 1, 2017 · ClockΔ19/Δ19 mice develop age-dependent increases in heart weight, hypertrophy, dilation, impaired contractility, and reduced myogenic responsiveness. Young ClockΔ19/Δ19 …
002923 - Clock Strain Details - The Jackson Laboratory
002923 C57BL/6J- Clock m1Jt /J These mice carry an ENU-induced mutation characterized by a lengthening of their circadian period.
Female ClockΔ19/Δ19 mice are protected from the development …
Sep 12, 2017 · Previously, we showed that disruption of the circadian mechanism factor CLOCK in male Clock Δ19/Δ19 mice led to development of age-dependent cardiomyopathy. Here, we …
Cd19-Cre Mice | Cre Mouse Lines | Research Models - Cyagen
In Cd19-Cre mice, Cre recombinase is expressed mainly in B cells in tissues such as peripheral blood, spleen, and bone marrow, whereas there is no Cre recombinase activity in T cells. …