Jan 15, 2021 · Asparagine endopeptidase (AEP) is a lysosomal protease implicated in the pathology of Alzheimer's disease (AD). It is known to cleave the axonal microtubule associated protein, Tau, and amyloid precursor protein (APP), both of which might impede axon regeneration following peripheral nerve injury (P …

As an AEP team member, you'll connect customers to energy and opportunity. Help us transform the industry and power possibilities.

Nov 29, 2023 · Here, we show an optimized asparagine endopeptidase (AEP, also known as δ-secretase) inhibitor, #11 A, that displays an orderly in vivo pharmacokinetics/pharmacodynamics (PK/PD) relationship and...

This review summarizes our current understanding of the crucial role of the C/EBPβ/AEP pathway in driving AD pathogenesis by cleaving multiple critical AD players, including APP and Tau, explaining the roles and the mechanisms of FSH in increasing the susceptibility to AD in postmenopausal females.

Mar 31, 2021 · Pharmacological inhibition of AEP can intervene and prevent AD-like pathological progress in the model of sporadic AD. The up-regulated AEP in the brain could be a promising target for early treatment of AD.

Visit AEP.com | Investors | AEP Careers | Electric Rates | Customer Choice | Requirements for Service

Mar 4, 2025 · Bullish – Bearish statement provided by AEP Energy Trading March 3rd, 2025 – Gas and power prices kicked off the week on a high note. Midday model runs showed increased demand, pushing natural gas up by more than 24 cents at the front of the curve.

Oct 1, 2024 · WASHINGTON, DC — The American Edge Project, a coalition of two dozen domestic organizations, will air its latest ad, “Edward,” during tonight’s Vice Presidential Debate, which will be broadcast on CBS.

Asparagine endopeptidase (AEP, mammalian legumain, δ-secretase; EC 3.4.22.34) is a proteolytic enzyme from C13 peptidase family which hydrolyses a peptide bond using the thiol group of a cysteine residue as a nucleophile (hence also called cysteine protease).

Jun 27, 2024 · WASHINGTON, DC — The American Edge Project (AEP), a coalition of nearly two dozen domestic organizations, will premiere its latest ad, “Sarah,” during the first presidential debate on CNN this Thursday, June 27. AEP’s advertisement is one of eight spots that will run nationally during the debate.