Brd4-independence in ground state pluripotency - Nature
Apr 16, 2018 · Brd4, a reader of histone acetylation, is a transcriptional co-activator implicated in the maintenance of embryonic stem cells (ESCs). A study now shows that Brd4 is dispensable …
Pluripotency transcription factors and Tet1/2 maintain Brd4
Apr 16, 2018 · Here, we show that Brd4 is dispensable for self-renewal and pluripotency of embryonic stem cells (ESCs). When maintained in their ground state, ESCs retain …
BRD4 regulates Nanog expression in mouse embryonic stem cells …
To explore Brd4 function in ESCs, we analyzed BRD4 protein levels in two different mouse ESC lines, TL1 and R1, before and after differentiation induced by withdrawal of leukemia inhibitory …
Pluripotency transcription factors and Tet1/2 maintain Brd4 …
In metastable ESCs, Brd4 independence can be achieved by increased expression of pluripotency transcription factors including STAT3, Nanog or Klf4 so long as the DNA …
Flipping a switch on BRD4: How to control the do-it-all - Cell Press
Nov 21, 2024 · In this issue, Devaiah et al. identify JNK-catalyzed phosphorylation to convert bromodomain-containing protein 4 (BRD4) from a chromatin regulator to a transcription activator.
IκB kinase‐α coordinates BRD4 and JAK/STAT ... - The EMBO Journal
Sep 22, 2023 · Here, BET family protein BRD4 is identified as a novel IKK‐α substrate, providing chemoresistance by inhibiting apoptosis prior to enhanced DNA damage repair, via STAT3 …
BRD4 is a newly characterized transcriptional regulator that …
BRD4 (bromodomain containing 4) can recruit transcriptional regulatory complexes to acetylated chromatin and positively modulate several biological processes. 4 Accordingly, many studies …
BRD4 localization to lineage-specific enhancers is associated …
Jan 9, 2017 · The Bromodomain-containing Protein-4 (BRD4) was previously shown to control the transcription of defined subsets of genes in various cell systems. In this study we examined …
Sep 22, 2023 · BRD4 by IKK-a is required for its chromatin-binding at target genes upon DNA damage. Moreover, IKK-a induces the NF-jB-dependent transcription of the cytokine LIF, …
Distinct Roles of Brd2 and Brd4 in Potentiating the Transcriptional ...
In this study, we report that the BET family members Brd2 and Brd4 exert distinct genomic functions at genes whose transcription they co-regulate during mouse T-helper 17 (Th17) cell …