Jan 24, 2023 · BRD4-NUT, a driver fusion mutant in rare and highly aggressive NUT carcinoma, acts in aberrant transcription of anti-differentiation genes by recruiting histone …

Jan 15, 2003 · These findings establish a model to elucidate the oncogenic consequences of unscheduled NUT expression and altered BRD4 function. Very few fusion oncogenes have …

NUT midline carcinoma (NMC), a subtype of squamous cell cancer, is driven by the creation of a translocation oncoprotein, BRD4-NUT. Alekseyenko et al. found that BRD4-NUT forms …

Jul 24, 2023 · Aberrant formation of biomolecular condensates has been proposed to play a role in several cancers. The oncogenic fusion protein BRD4-NUT forms condensates and drives …

Jan 15, 2021 · BRD4-NUT combines the chromatin-binding bromo- and extraterminal domain-containing (BET) protein, BRD4, with an unstructured, poorly understood protein, NUT, which …

Dec 1, 2023 · NUT carcinoma (NC) is an aggressive squamous carcinoma defined by the BRD4–NUT fusion oncoprotein. Routinely effective systemic treatments are unavailable for …

BRD4-NUT combines the chromatin-binding bromo- and extraterminal domain-containing (BET) protein, BRD4, with an unstructured, poorly understood protein, NUT, which recruits and …

Sep 1, 2018 · BRD4 is an epigenetic reader that binds to acetyl-histone. Fusion to the NUT protein results in recruitment of p300/CBP, a histone acetyltransferase, leading to regional …

Dec 1, 2023 · NUT carcinoma (NC) is an aggressive squamous carcinoma defined by the BRD4-NUT fusion oncoprotein. Routinely effective systemic treatments are unavailable for most NC …

BRD4-NUT blocks differentiation and maintains tumor growth through a potent chromatin modifying mechanism. OTX015/MK-8628, a novel oral BET inhibitor, targets BRD2/3/4/T with …

May 9, 2024 · About 70% of NUT carcinoma is associated with chromosome translocation events that lead to the formation of a BRD4::NUTM1 fusion gene. Because the BRD4::NUTM1 gene …

Nov 9, 2015 · Molecular analysis of the tumor tissue identified a novel in-frame BRD4-NUT transcript, with BRD4 exon 15 fused to the last 124 nucleotides of NUT exon 2 (BRD4-NUT …

NUT carcinoma (NC) is an aggressive squamous carcinoma defined by the BRD4–NUT fusion oncoprotein. Routinely effective systemic treatments are unavailable for most NC patients. The …

Mar 13, 2024 · We report a case of a 59-year-old man who underwent a biopsy of a 3-cm plantar mass, which showed BRD4::NUTM1 fusion. The tumor was a poorly differentiated dermal …

Jan 24, 2023 · BRD4-NUT, a driver fusion mutant in rare and highly aggressive NUT carcinoma, acts in aberrant transcription of anti-differentiation genes by recruiting histone …

That BRD4-NUT promotes gene expression prompted us to investigate epigenetic gene silencing as a parallel pathway that regulates NC growth. We find that BRD4-NUT-mediated gene …

Oct 1, 2021 · NUT carcinoma is a rare but aggressive solid tumor that can be diagnosed by presence of the BRD4-NUT fusion. This series presents 31 cases of solid tumors that harbor …

Dec 14, 2023 · In our study, we introduced the BRD4-NUT oncogene into 3T3 cells to facilitate the formation of tumors both in vitro and in vivo, thereby simulating nut carcinoma and …

1 day ago · This mechanism is especially relevant in malignancies like acute myeloid leukemia (AML) and NUT midline carcinoma, where BRD4 dependency is pronounced. Beyond …

Jul 15, 2015 · NUT midline carcinoma (NMC), a subtype of squamous cell cancer, is one of the most aggressive human solid malignancies known. NMC is driven by the creation of a …