Sep 17, 2018 · Here, we investigated the transcriptional dependencies of transformed cells to the transcription factors YAP and TAZ. YAP/TAZ physically engage the general coactivator …

To start, YAP/TAZ recruit the general coactivator bromodomain-containing protein 4 (BRD4), in fact dictating the genome-wide association of BRD4 to chromatin, and endowing to YAP/TAZ …

BRD4 inhibition by BET inhibitors (BETi) has been shown to effectively suppress downstream gene transcription even when YAP is overexpressed, suggesting that YAP/TAZ function …

Mar 23, 2020 · Here we demonstrate that TAZ forms nuclear condensates through liquid–liquid phase separation to compartmentalize its DNA-binding cofactor TEAD4, coactivators BRD4 …

The transcriptional co-activator Yes-associated protein (YAP) and its paralogue transcriptional co-activator with PDZ-binding motif (TAZ) are another set of key players linked to cancer cell …

Mar 23, 2020 · YAP and TAZ, paralogous mammalian genes, act as the key transcriptional effectors of the Hippo pathway. Two recent reports show that both YAP and TAZ form …

Jan 1, 2020 · Recent work has indeed revealed that BRD4-mediated transcriptional addiction in different cancer cells is also dependent on YAP/TAZ, which recruits BRD4 at high levels at …

Here, we investigated the transcriptional dependencies of transformed cells to the transcription factors YAP and TAZ. YAP/TAZ physically engage the general coactivator bromodomain …

Oct 29, 2021 · Recent work on the YAP/TAZ co-activators has been instrumental to break new ground into this outstanding issue, revealing that tumor cells hijack growth programs that are …

May 2, 2023 · BRD4 is a cofactor that is required for YAP/TAZ-mediated sustained oncogene transcription in cancer, as evidenced by the dynamics of YAP/TAZ and its engagement with …