As mentioned above, bifidobacteria degrade hexose sugars through a particular metabolic pathway, termed the “bifid shunt”, where the fructose-6-phosphoketolase enzyme (EC 4.1.2.2) plays a key role (Fig. 2) . This enzyme is considered to be a taxonomic marker for the family of Bifidobacteriaceae .

Dec 3, 2019 · Bifidobacteria degrade the hexose sugars glucose and fructose through a unique pathway named “bifid shunt”, which is centred on the key enzyme fructose-6-phosphate phosphoketolase 9.

Bifidobacteria lack a number of key enzymes involved in the Emden-Meyerhof Parnas (EMP) pathway, instead, bifidobacteria metabolize hexose sugars through a metabolic pathway named the “bifid shunt” which is centered around the key enzyme, fructose-6-phosphoketolase (EC 4.1.2.2) (Figure 1; De Vries and Stouthamer, 1967; De Vuyst et al., 2014).

Dec 9, 2021 · However, all bifidobacteria use a characteristic hexose fermentation pathway, known as the bifid shunt, for carbon dissimilation 4, 7, due to the lack of 6-phosphofructokinase (EC 2.7.1.11),...

1 day ago · The bifid shunt begins with carbohydrate uptake through ATP-binding cassette (ABC) transporters and phosphoenolpyruvate phosphotransferase systems (PTS). These mechanisms facilitate the import of mono- and oligosaccharides, which are then broken down by intracellular glycosidases. Once inside the cell, carbohydrates are converted into fructose ...

Jan 1, 2019 · To obtain higher carbon yields, we constructed a carbon conservation pathway named EP-bifido pathway in Escherichia coli by combining Embden-Meyerhof-Parnas Pathway, Pentose Phosphate Pathway and “bifid shunt”, to generate high yield acetyl-CoA from glucose.

Bifidobacteria are a minor fraction of the human colon microbiota with interesting properties for carbohydrate degradation. Monosaccharides such as glucose and fructose are degraded through the bifid shunt, a dedicated pathway involving phosphoketolase activity.

In bifidobacteria, phosphoketolase (PKT) plays a key role in the central hexose fermentation pathway called “bifid shunt.”

Nov 28, 2019 · Here, we show that two predicted LacI-type transcription factors (TFs), designated AraQ and MalR1, are involved in regulating the central, carbohydrate-associated metabolic pathway (the so-called...

Feb 4, 2021 · Central carbohydrate metabolism in bifidobacteria is represented by the ‘Bifid Shunt’, which is regulated by two LacI-type regulators, designated AraQ and MalR1 (Lanigan et al., 2019), employing a mechanism that is reminiscent to that reported for C.