It provides the United States Air Force (USAF) with a heavy intercontinental-range strategic airlift capability, one that can carry outsized and oversized loads, including all air-certifiable cargo. The Galaxy has many similarities to the smaller Lockheed C-141 Starlifter and the later Boeing C-17 Globemaster III.

C5a is a protein fragment released from cleavage of complement component C5 by protease C5-convertase into C5a and C5b fragments.

Dec 18, 2017 · Its primary mission is to transport cargo and personnel for the Department of Defense. The C-5M is a modernized version of the legacy C-5 designed and manufactured by Lockheed Martin. Currently the U.S. Air Force owns and operates 52 C-5B/C/M.

Herein, we review human and animal data describing the cellular and molecular mechanisms of C5a in the development of inflammatory disorders, sepsis, acute lung injury, ischemia-reperfusion injury, and asthma.

The C5a receptor also known as complement component 5a receptor 1 (C5AR1) or CD88 (Cluster of Differentiation 88) is a G protein-coupled receptor for C5a. It functions as a complement receptor. [5] C5a receptor 1 modulates inflammatory responses, obesity, development and cancers.

This review provides a comprehensive overview of human C5a in the context of its structure and signaling under several pathophysiological conditions, including the current and future therapeutic applications targeting C5a.

There is accumulating evidence that the complement activation product, C5a, can orchestrate cellular immune functions. IL-27 (p28/EBI3) is an emerging key player essential for regulating inflammatory responses and T cells. Here, we report that C5a ...

The hC5aR2, unlike hC5aR1, binds C5a and C5a des Arg using distinct mechanisms, with its N-terminus containing Tyr and acidic residues critical for binding of C5a des Arg but not of C5a. However, the controversy arose whether C5aR2 could bind other ligands.

The split product of the complement protein, C5, is C5a and is an extremely potent pro-inflammatory peptide that interacts with two C5a receptors, C5aR and C5L2, present on surfaces of phagocytes as well as other cell types.

May 10, 2020 · Complement factor C5a is an integral constituent of the complement cascade critically involved in the innate immune response, and it exerts its functions via two distinct receptors, C5aR1 and C5aR2.