Sep 21, 2020 · Restricting CD36 at either palmitoylated or depalmitoylated state eliminates its FA uptake activity, indicating an essential role of dynamic palmitoylation of CD36. Furthermore, blocking...

CD36 (cluster of differentiation 36), also known as platelet glycoprotein 4, fatty acid translocase (FAT), scavenger receptor class B member 3 (SCARB3), and glycoproteins 88 (GP88), IIIb (GPIIIB), or IV (GPIV) is a protein that in humans is encoded by the CD36 gene.

Several proteins have been implicated in fatty acid (FA) transport by enterocytes including the scavenger receptor CD36 (SR-B2), the scavenger receptor B1 (SR-B1) a member of the CD36 family and the FA transport protein 4 (FATP4). Here, we review ...

Sep 24, 2021 · We showed that CD36 directly interacts with FABP4 to regulate fatty acid import, transport, and metabolism. CD36 and FABP4 inhibition induces apoptosis in tumour cells.

Nov 20, 2024 · Indeed, Cd36, Fabp4, and Fatp1 gene expression was shown to increase in 3T3-L1 adipocytes treated with PPARγ agonists [33, 88]. Since N-3 PUFA can activate PPARγ in WAT, this provides a plausible mechanism by which N-3 PUFA can increase the expression of these fatty acid transport proteins.

CD36 is a scavenger receptor that functions in high affinity tissue uptake of long chain fatty acids (FA) and contributes under excessive fat supply to lipid accumulation and metabolic dysfunction. This review describes recent evidence regarding the CD36 FA binding site and a potential mechanism for FA transfer.

CD36 is a type 2 cell surface scavenger receptor widely expressed in many immune and non-immune cells. It functions as both a signaling receptor responding to DAMPs and PAMPs, as well as a long chain free fatty acid transporter.

Oct 18, 1999 · Identification of the mammalian membrane fatty acid transporter (s) has been the focus of active investigation by several research groups. In this review we discuss three candidate proteins: FABPm, FAT/CD36 and FATP which have been cloned and are …

Aug 13, 2008 · Overexpression of FAT/CD36 and FATP4 increased long chain fatty acid uptake. The uptake of long chain fatty acids was cholesterol and sphingolipid dependent. Floating experiments showed that there are two pools of FAT/CD36, one found in DRMs and another outside of these domains.

Recent data show that CD36 is indeed increased in liver of morbidly obese patients and correlated to free FA levels 22. It has also been shown that downregulation of CD36 can prevent steatohepatitis in hyperlipidemic mice 57. This way CD36 is also a target for the treatment of NAFLD or NASH.