CUL3 - Wikipedia
Cullin 3-RING complex consists of Cullin 3 protein, RING-box protein 1 (RBX1), which recruits the ubiquitin-conjugating enzyme (E2), and a Bric-a-brac/Tramtrack/Broad (BTB) protein, a …
The functions and effects of CUL3-E3 ligases mediated
Jul 20, 2022 · The E3 ligase complex CUL3 KLHL20 locates to TGN in an Arf-family GTPase-dependent manner that controls many aspects of Golgi-mediated vascular transport (Yuan et …
CUL3 Gene - GeneCards | CUL3 Protein | CUL3 Antibody
Dec 24, 2024 · CUL3 (Cullin 3) is a Protein Coding gene. Diseases associated with CUL3 include Pseudohypoaldosteronism, Type Iie and Neurodevelopmental Disorder With Or Without …
A conserved N-terminal motif of CUL3 contributes to assembly
May 6, 2024 · Here, we report the cryo-EM structure of the dimeric CRL3 KLHL22 complex and reveal a conserved N-terminal motif in CUL3 that contributes to the dimerization assembly and …
Cullin 3-based ubiquitin ligases as master regulators of …
Based on studies about differentiation programs of mesenchymal stem cells (MSCs), including myogenesis, neurogenesis, chondrogenesis, osteogenesis and adipogenesis, we propose that …
The Cullin3-Rbx1-KLHL9 E3 ubiquitin ligase complex ... - Cell Press
Jan 28, 2025 · We report that the CUL3-RBX1-KLHL9 E3 ubiquitin ligase complex is translocated to the lysosome and ubiquitinates Rheb in response to amino acid stimulation. KLHL9 serves …
CRL3s: The BTB-CUL3-RING E3 Ubiquitin Ligases - PubMed
Here, we review the most recent studies on CRL3 complexes, with a focus on the model for CUL3 assembly with its BTB-containing substrate receptors. Also, we summarize the current …
Co-adaptor driven assembly of a CUL3 E3 ligase complex
Using CUL3 KLHL12 as a model, we found that its co-adaptor PEF1-ALG2 initiates CRL3 formation by releasing KLHL12 from an assembly inhibitor at the endoplasmic reticulum, …
Original research: CUL3/SPOP complex prevents immune escape …
Oct 5, 2022 · All in all, CUL3/SPOP formed a complex to promote PD-L1 degradation to inhibit ovarian cancer cell immune escape and increase chemosensitivity, offering a therapeutic …
CUL3 gene - MedlinePlus
Cullin-3 is a core piece of a complex known as an E3 ubiquitin ligase. E3 ubiquitin ligases tag proteins with molecules called ubiquitin. Ubiquitin signals specialized cell structures known as …