Cullin 3 is a protein that in humans is encoded by the CUL3 gene. [5] [6] [7] Cullin 3 protein belongs to the family of cullins which in mammals contains eight proteins (Cullin 1, Cullin 2, Cullin 3, Cullin 4A, Cullin 4B, Cullin 5, Cullin 7 and Cullin 9). [8]

The CUL3 gene provides instructions for making a protein called cullin-3. Learn about this gene and related health conditions.

Dec 24, 2024 · CUL3 (Cullin 3) is a Protein Coding gene. Diseases associated with CUL3 include Pseudohypoaldosteronism, Type Iie and Neurodevelopmental Disorder With Or Without Autism Or Seizures. Among its related pathways are Class I MHC mediated antigen processing and presentation and MAPK family signaling cascades.

Feb 9, 2025 · Title: Knockdown of cullin 3 inhibits progressive phenotypes and increases chemosensitivity in cholangiocarcinoma cells. A comparative analysis indicates SLC7A11 expression regulate the prognostic value of KEAP1-NFE2L2-CUL3 mutations in human uterine corpus endometrial carcinoma.

Gene ID: 8452, updated on 9-Feb-2025. This gene encodes a member of the cullin protein family. The encoded protein plays a critical role in the polyubiquitination and subsequent degradation of specific protein substrates as the core component and scaffold protein of …

Sep 1, 2019 · Cullin-3 targets cyclin E for ubiquitination and controls S phase in mammalian cells

Cullin 3 (Cul3) family of ubiquitin ligases comprises three components, the RING finger protein RBX1, the Cul3 scaffold, and a Bric-a-brac/Tramtrack/Broad complex (BTB) protein. The BTB protein serves as a bridge to connect Cul3 to substrate and is functionally equivalent to the combination of subst …

Cullin-RING-ligases (CRLs) comprise the largest class of multisubunit E3 ubiquitin ligases, which regulate a broad range of cellular processes. Cullin3 (Cul3) recently emerged as an important regulator of intracellular trafficking, in particular secretion and endosome maturation.

Based on studies about differentiation programs of mesenchymal stem cells (MSCs), including myogenesis, neurogenesis, chondrogenesis, osteogenesis and adipogenesis, we propose that CRL3 complexes evolved to fulfill a pivotal role in mammalian cell differentiation.

The CUL3 gene encodes a scaffolding component of the Cullin-RING ligase (CRL) complex, which belongs to a class of E3 ubiquitin ligases that mediate polyubiquitination of specific target proteins destined for degradation (summary by Nakashima et al., 2020).