Dec 4, 2011 · Cullin proteins are molecular scaffolds that have crucial roles in the post-translational modification of cellular proteins involving ubiquitin. The mammalian cullin protein …

Dec 24, 2024 · CUL1 (Cullin 1) is a Protein Coding gene. Diseases associated with CUL1 include Vaccinia and Uv-Sensitive Syndrome. Among its related pathways are Regulation of activated …

Cullin-RING ubiquitin ligases (CRLs), such as Cul1 (SCF) play an essential role in targeting proteins for ubiquitin-mediated destruction; as such, they are diverse in terms of composition …

Herein, this review briefly provides current perspectives on cullin protein functions, and mainly summarizes and discusses molecular mechanisms of cullin proteins in tumorigenesis. …

Dec 10, 2024 · Cullin1 is a novel marker of poor prognosis and a potential therapeutic target in human breast cancer. Bai J, et al. Ann Oncol, 2013 Aug. PMID 23592700. Aberrant …

Cullin 1 (CUL1) Promotes Primary Ciliogenesis through the Induction of Ubiquitin-Proteasome-Dependent Dvl2 Degradation. Abnormal Cullin1 neddylation-mediated p21 accumulation …

Aug 18, 2020 · In this study, we investigate the intracellular distribution of the cullins CUL1, 2, 3, 4A, 4B, 5, and 7. We further analyze their chromatin-association, their likely interactions with …

There are seven cullins in mammals (CUL1 to CUL3, CUL4a, CUL4b, CUL5, CUL7 and the closely related p53-associated parkin-like cytoplasmic protein (Parc) in Homo sapiens, Mus …

Here, we discover that Cullin1 (CUL1), a key component of the Skp1-Cullin1-F-box E3 ligase, plays a critical role in controlling the NLRP3 inflammasome. CUL1 represses inflammasome …

Apr 1, 2015 · Cullin1 (Cul1) is a scaffold protein of the ubiquitin E3 ligase Skp1/Cullin1/Rbx1/F-box protein complex, which ubiquitinates a broad range of proteins involved in cell-cycle …