Cullin-RING Ligase 5: Functional characterization and its role ... - PubMed
Cullin-RING ligase 5 (CRL5) is a multi-protein complex and consists of a scaffold protien cullin 5, a RING protein RBX2 (also known as ROC2 or SAG), adaptor proteins Elongin B/C, and a …
CUL5 - Wikipedia
Cullin-5 is a protein that in humans is encoded by the CUL5 gene. [5][6][7] The mammalian gene product was originally discovered by expression cloning, due to the protein's ability to mobilize …
Cullin5 drives experimental asthma exacerbations by modulating …
Jan 4, 2024 · Here using mouse models we find that Cullin5 (CUL5), a key component of Cullin-RING E3 ubiquitin ligase 5, is upregulated and associated with increased neutrophil count and …
Cullin-RING Ligase 5: Functional characterization and its role in …
Dec 1, 2020 · Cullin-RING ligase 5 (CRL5) is a multi-protein complex and consists of a scaffold protien cullin 5, a RING protein RBX2 (also known as ROC2 or SAG), adaptor proteins Elongin …
A Comprehensive Review of Biological Roles and Interactions of Cullin-5 …
Feb 11, 2022 · The Cullin-5 ubiquitin ligase (Cul5) possesses a variety of substrates that maintain the process of ubiquitination as well as proteasomal degradation. It regulates cell …
The functions and properties of cullin-5, a potential ... - PubMed
Feb 15, 2020 · Cullin-5 (CUL5), a scaffold protein in active cullin-RING ubiquitin ligase (CRL) complexes, is a member of the cullin family of proteins. The CUL5-type ubiquitin ligase can …
Cullin-5 controls the number of megakaryocyte-committed stem …
Dec 27, 2024 · Cullin-5 regulates production of megakaryocyte-committed stem cells to prevent excess megakaryopoiesis. Cullin-5-deficient megakaryopoiesis is largely independent of TPO …
Cullin-5 (CUL5) as a potential prognostic marker in a pan-cancer ...
CUL5 expression is associated with CD8 + T-cell infiltration levels in uveal melanomas and head and neck squamous cell carcinomas, and we observed a positive relationship between CUL5 …
Cullin5 deficiency promotes small-cell lung cancer metastasis by ...
Jan 28, 2019 · Through genome-scale screening for key regulators of mouse Rb1–/– Trp53–/– SCLC metastasis using the pooled CRISPR/Cas9 library, we identified Cullin5 (CUL5) and …
Cullin5 drives experimental asthma exacerbations by modulating …
Jan 4, 2024 · Here using mouse models we find that Cullin5 (CUL5), a key component of Cullin-RING E3 ubiquitin ligase 5, is upregulated and associated with increased neutrophil count and …
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