Cyclin E is a member of the cyclin family. Cyclin E binds to G 1 phase Cdk2, which is required for the transition from G 1 to S phase of the cell cycle that determines initiation of DNA duplication.

The Cyclin E/Cdk2 complex is a structure composed of two proteins, cyclin E and cyclin-dependent kinase 2 (Cdk2). Similar to other cyclin/Cdk complexes, the cyclin E/Cdk2 dimer …

Cyclin E binds and activates the kinase Cdk2 and by phosphorylating its substrates, the so-called "pocket proteins", the cyclic/Cdk2 complexes initiate a cascade of events that leads to the …

Nov 24, 2021 · Cyclin E/CDK2 complex mostly controls cell cycle progression and DNA replication through phosphorylation of specific substrates. Oncogenic activation of Cyclin …

Recent reports demonstrate that inappropriate cyclin E expression may have far-reaching biological consequences for cell physiology, including altering gene expression programs …

Cyclin E overexpression not only accelerates the proliferation and division of tumor cells by promoting cell cycle transformation but also induces the expression of related products, …

E-type cyclins, collectively called cyclin E, represent key components of the core cell cycle machinery. In mammalian cells, two E-type cyclins, E1 and E2, activate cyclin-dependent …

May 27, 2021 · E-type cyclins, collectively called cyclin E, represent key components of the core cell cycle machinery. In mammalian cells, two E-type cyclins, E1 and E2, activate cyclin …

Cyclin E is a protein that plays a crucial role in cell-cycle regulation by facilitating centrosome replication and allowing premature entry of cells into the S phase. It is often associated with …

We propose that cyclin E facilitates MCM loading in a kinase-independent fashion, through physical interaction with CDT1 and MCM. Our work indicates that—in addition to their function …

In normal cell cycles, E-type cyclins (Cyclin E1 and Cyclin E2, CCNE1 and CCNE2 genes) associate with CDK2 to promote G1/S transition. Cyclin E/CDK2 complex mostly controls cell …

Cyclin E2 is a protein that in humans is encoded by the CCNE2 gene. It is a G1 cyclin that binds Cdk2 and is inhibited by p27(Kip1) and p21(Cip1). [1] It plays a role in the G1/S portion of the …

Feb 2, 2023 · Cyclin E expression suppresses p53-dependent senescence after mitotic bypass, allowing cells to complete endoreduplication. Our results indicate that p53 can contribute to …

Apr 18, 2005 · In this review, we discuss the regulation and functions of cyclin E in normal and neoplastic mammalian cells. Cyclin-dependent kinases control cell cycle transitions. These …

Sep 1, 2021 · Cyclin E, a cell cycle protein, has a variety of non-canonical, cell cycle-independent physiological roles, such as regulating liver function, neurophysiology, spermatogenesis, and …

Aug 1, 2004 · Cyclin E binds and activates the kinase Cdk2 and by phosphorylating its substrates, the so-called “pocket proteins”, the cyclic/Cdk2 complexes initiate a cascade of events that …

Cyclin E has multiple functions in cell cycle progression, both Cdk-dependent and Cdk-independent. Cyclin E is necessary for the formation of pre-replication complexes on DNA as …

Sep 15, 2020 · This review summarizes the specific processes by which cyclin E regulates the cell cycle, its relationship to chemotherapy resistance in cancer, and its potential as a clinical …

Nov 9, 2016 · E-type cyclins (cyclins E1 and E2) are components of the cell cycle machinery that has been conserved from yeast to humans. The major function of E-type cyclins is to drive cell …

Feb 24, 2025 · The cyclin E–CDK2 complex further phosphorylates Rb, disinhibiting E2F, which subsequently travels to the nucleus to modulate transcription. The cyclin E–CDK2 complex is …