DNA ligase is an enzyme that plays a central role in DNA repair and replication. Its primary function is to join together or "ligate" the phosphate-sugar backbones of adjacent DNA strands.

As DNA polymerases synthesize new DNA strands, small gaps, or "nicks," are created between the Okazaki fragments on the lagging strand. DNA ligase repairs these nicks by sealing the phosphodiester bonds, thus forming a continuous and functional DNA molecule.

With the recent rise of the “molecular glue” type of protein degraders, which tighten and simplify the connection of an E3 ligase with a disease-causing protein for ubiquitination and subsequent degradation, new therapies for unmet medical needs are being designed and developed.

Oct 7, 2024 · Ligase acts like a molecular glue, joining two strands of DNA together by forming a bond between them. This process is vital for maintaining the integrity of genetic information. Without ligase, cells would struggle to repair DNA damage, leading to mutations and potentially serious health issues.

Jun 3, 2020 · Our studies demonstrate that chemical alteration of surface-exposed moieties can confer gain-of-function glue properties to an inhibitor, and we propose this as a broader strategy through which...

Study with Quizlet and memorize flashcards containing terms like Ligase, Helicase, gyrase and more.

Study with Quizlet and memorize flashcards containing terms like Where does DNA replication occur in Eukaryotes?, When does DNA replication happen during the cell cycle?, Does DNA replication happen during mitosis? and more.

"the gluer" which glues the DNA fragments together. Study with Quizlet and memorize flashcards containing terms like Helicase, DNA Polymerase, Primase and more.

May 28, 2020 · A ligase is any enzyme that is able to accelerate/begin the joining of two large molecules (this process is also known as litigation). It does this by forming a new chemical bond between the two molecules. Because ligase helps to join or "glue" molecules together, it can be called The Gluer. Hope this helps!