NEDD8 nucleates a multivalent cullin–RING–UBE2D ubiquitin …
Feb 12, 2020 · NEDD8 acts as a nexus that binds disparate cullin elements and the RING-activated ubiquitin-linked UBE2D. Local structural remodelling of NEDD8 and large-scale …
The NEDD8 Conjugation Pathway and Its Relevance in Cancer …
Conjugation of NEDD8 to cullin activates the ubiquitin ligase activity of the CRL, and removal of NEDD8 by the COP9 signalosome facilitates dissociation of CRL components. Unneddylated …
NEDD8 — its role in the regulation of Cullin-RING ligases
Oct 1, 2018 · NEDD8 promotes the stability and function of Cullin-RING E3 ligases. COP9 signalosome deneddylates Cullins and destabilizes E3 ligase complexes. CAND1 serves as …
Protein neddylation and its role in health and diseases
Apr 5, 2024 · The yeast defective in cullin neddylation 1 (DCN1) protein, which bind to both NEDD8 E2 enzymes and cullins to increase neddylation efficiency, is considered as the main …
Nedd8 on cullin: building an expressway to protein destruction
Mar 15, 2004 · Three, studies using a variety of genetic model systems have established an essential role for Nedd8 in cell cycle control and in embryogenesis by upregulating the …
A new NEDD8-ligating system for cullin-4A - PMC
The major target protein modified by NEDD8 was found to be Hs–cullin-4A (Cul-4A), a member of the family of human cullin/Cdc53 proteins functioning as an essential component of a …
NEDD8 and ubiquitin ligation by cullin-RING E3 ligases
NEDD8 steers UBE2M~NEDD8 by aligning two charged residues unique to NEDD8 to RBX1’s Trp35. Other residues in between RBX1’s cullin-binding strand and catalytic RING domain …
NEDD8 nucleates a multivalent cullin-RING-UBE2D ubiquitin …
NEDD8 acts as a nexus that binds disparate cullin elements and the RING-activated ubiquitin-linked UBE2D. Local structural remodelling of NEDD8 and large-scale movements of CRL …
NEDD8-its role in the regulation of Cullin-RING ligases
Biochemical and structural studies aiming at understanding the role of NEDD8 in CRL function have now resulted in a convincing model of how neddylation and deneddylation …
Structural Insights into NEDD8 Activation of Cullin-RING Ligases ...
Sep 9, 2008 · In NEDD8ylated CRL structures, the cullin WHB and Rbx1 RING subdomains are dramatically reoriented, eliminating a CAND1-binding site and imparting multiple potential …