Assays used in preclinical development to support PK/PD analysis typically include drug or surrogate molecule assays, target engagement or biomarker assays, and ADA assays. …

Pharmacokinetics (from Ancient Greek pharmakon "drug" and kinetikos "moving, putting in motion"; see chemical kinetics), sometimes abbreviated as PK, is a branch of pharmacology …

Use of a single PK assay for quantification of multiple products requires a scientifically sound testing strategy to evaluate bioanalytical comparability of the test products within the method, …

Sep 9, 2015 · While extensive discussion of how Absorption, Distribution, Metabolism, and Excretion (ADME) of compounds affects their ultimate pharmacokinetics (PK) is beyond the …

PK evaluations help to define the proper dosage, route, and schedule of administration during preclinical and clinical studies. BioAgilytix provides PK assay development, validation, and …

To support PK studies at all phases of development, we offer assay development, validation, and implementation using ELISA and Meso Scale Discovery (MSD) assays for biologics, and flow …

Results: A PK assay strategy was developed that included comprehensive novel reagent and assay characterization approaches for the ADC ado-trastuzumab emtansine (T-DM1). …

To interpret pharmacokinetic (PK) data of biotherapeutics, it is critical to understand which drug species is being measured by the PK assay. For therapeutic antibodies, it is generally …

pharmacokinetic (PK) assays are required to measure the biosimilar and reference products with comparable precision and accuracy. The most optimal approach is to develop a single PK …

Meet CellCarta's PK assays for biologics. Discover how our tailored assays offer accuracy and efficiency in pharmacokinetic analysis.