This document translates screening guidance and clinical considerations from the USPSTF and CDC into a decision tree format to guide implementation. (e.g., every 3 to 6 months) if they …

Traditional Sequence Algorithm Reverse Sequence Screening Algorithm Syphilis unlikely ORDER A different treponemal test than used for initial ... Fakile Y, et al. CDC laboratory …

Overall, the decision to use the traditional or reverse syphilis algorithm should be based on patient population, test costs, volume, and workflow. Clinicians should correlate the patient’s …

When ordering an RPR=rapid plasma reagin (non-treponemal) and results are positive, order a REFLEX treponemal test such as TP-PA=Treponema pallidum particle agglutination assay. …

CDC recommends that a specimen with reactive EIA/CIA results be tested reflexively with a quantitative nontreponemal test (e.g., RPR or VDRL). If test results are discordant, the …

Reverse Sequence Screening Algorithm Explained: As an alternative to the traditional syphilis screening algorithm, many laboratories utilize the reverse syphilis screening algorithm. This …

Untreated or recently treated syphilis. See CDC** guidelines for treatment. Follow rapid plasma reagin titers. Possible syphilis (early or latent) or previously treated syphilis. Historical and …

Syphilis Reverse Test Algorithm *If previously treated, no further treatment unless re-exposure is suspected. If re-exposure, repeat RPR in 2-4 weeks. Those without a history of treatment for …

Flow chart of patient results for the traditional (A) and reverse (B) syphilis testing algorithms. Percentages represent the percent of the total number of screening tests in the traditional and …

With the positivity rate increasing so significantly, we recommend that providers initially screen with the Syphilis Ab Screen Algorithm rather than the RPR. The algorithm is a reverse …