Enoyl-CoA hydratase (ECH) or crotonase[1] is an enzyme EC 4.2.1.17 that hydrates the double bond between the second and third carbons on 2-trans/cis-enoyl-CoA: [2] ECH is essential to metabolizing fatty acids in beta oxidation to produce both acetyl CoA and energy in …

Enoyl-CoA- (∆) isomerase (EC 5.3.3.8, also known as dodecenoyl-CoA- (∆) isomerase, 3,2-trans-enoyl-CoA isomerase, ∆3 (cis),∆2 (trans)-enoyl-CoA isomerase, or acetylene-allene isomerase, [1] is an enzyme that catalyzes the conversion of cis- or trans - double bonds of coenzyme A (CoA) bound fatty acids at gamma- carbon (position 3) to trans doubl...

Jan 2, 2003 · Enoyl-CoA hydratase (ECH) catalyzes the second step in the physiologically important beta-oxidation pathway of fatty acid metabolism. This enzyme facilitates the syn-addition of a water molecule across the double bond of a trans-2-enoyl-CoA thioester, resulting in the formation of a β-hydroxyacyl-CoA thioester. The catalytic mechanism of this ...

Enoyl-CoA hydratase (Ech) catalyzes the second step in the physiologically important beta-oxidation pathway of fatty acid metabolism. The enzyme was reported to be associated with the progression, metastasis and drug resistance of cancers.

Sep 6, 2017 · Herein, we report that enoyl-CoA hydratase-1 (ECHS1), the enzyme involved in the oxidation of fatty acids (FAs) and branched-chain amino acids (BCAAs), senses nutrients and promotes mTOR...

Jan 2, 2003 · Enoyl-CoA hydratase (ECH) catalyzes the second step in the physiologically important beta-oxidation pathway of fatty acid metabolism. This enzyme facilitates the syn-addition of a water molecule across the double bond of a trans-2-enoyl-CoA thioester, resulting in the formation of a beta-hydroxyacyl …

Jan 16, 2023 · Oxidation of fatty acids occurs in multiple regions of the cell within the human body; the mitochondria, in which only beta-oxidation occurs; the peroxisome, where alpha- and beta-oxidation occur; and omega-oxidation, which occurs in the endoplasmic reticulum.

Mar 8, 2021 · Short-chain enoyl–coenzyme A (CoA) hydratase mediates histone crotonylation and contributes to cardiac homeostasis. A, Schematic diagram shows the metabolism of crotonyl-CoA. Crotonyl-CoA can be used by histone crotonyl-transferase (HCT; eg, P300) to promote histone crotonylation and gene transcription.

Mitochondrial short-chain enoyl-CoA hydratase 1 deficiency is an inborn error of metabolism characterized by delayed psychomotor development, neurological degeneration, increased lactic acid, and brain lesions in structures of the brain known as the basal ganglia.

Explain the stepwise β‑oxidation of fatty acids in the mitochondria, including the sequential reactions catalyzed by acyl-CoA dehydrogenase, enoyl-CoA hydratase, β‑hydroxyacyl-CoA dehydrogenase, and thiolase, and how these reactions yield acetyl-CoA, NADH, and FADH₂.