ARV-825 | BRD4 PROTAC Degrader - MedChemExpress
ARV-825 is a hetero-bifunctional proteolysis-targeting chimera that recruits BRD4 to the E3 ubiquitin ligase cereblon. ARV-825 actively recruits BRD4 to cereblon, resulting in the rapid …
ARV-825 | 99.45%(HPLC) | In Stock | PROTAC chemical
ARV-825 is a BRD4 Inhibitor that recruits BRD4 to the E3 ubiquitin ligase cereblon, leading to fast, efficient, and prolonged degradation of BRD4 and sustained down-regulation of MYC.
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BRD4 PROTAC degrader ARV-825 inhibits T-cell acute …
Apr 22, 2021 · ARV-825, comprising a BET inhibitor conjugated with cereblon ligand, was recently developed to attenuate the growth of multiple tumors in vitro and in vivo. However, the …
PROTAC Bromodomain Inhibitor ARV-825 Displays Anti-Tumor …
Nov 26, 2020 · ARV-825 is a novel BET inhibitor using proteolysis-targeting chimera (PROTAC) technology which degrades target proteins by the proteasome. In this study, we investigated …
ARV-825 ≥98% (HPLC) | Sigma-Aldrich - MilliporeSigma
ARV-825 is a hetero-bifunctional PROteolysis TArgeting Chimera (PROTAC) containing a BRD4 binding group (OTX-015) on one end, a linker arm, and a cereblon (CRBN) ubiquitin E3 ligase …
PROTAC Bromodomain Inhibitor ARV-825 Displays Anti-Tumor ... - PubMed
Nov 26, 2020 · ARV-825 is a novel BET inhibitor using proteolysis-targeting chimera (PROTAC) technology which degrades target proteins by the proteasome. In this study, we investigated …
Novel BET protein proteolysis-targeting chimera exerts ... - Nature
Feb 2, 2017 · The PROTAC (proteolysis-targeting chimera) ARV-825 recruits bromodomain and extraterminal (BET) proteins to the E3 ubiquitin ligase cereblon, leading to degradation of BET …
Arv-825 - Enzo
ARV-825 is a PROTAC targeting on BRD4, consisting of a BRD4-ligand JQ-1 linked to a cereblon E3 ligase ligand Pomalidomide, with K d s values of 90nM and 28nM for affinity to BD1 and BD2.
ARV-825 Demonstrates Antitumor Activity in Gastric Cancer via …
Oct 18, 2021 · ARV-825, a BRD4 inhibitor, could effectively suppress the growth and elevate the apoptosis of gastric cancer cells via transcription downregulation of c-MYC and PLK1. These …
ARV-825 (CAS 1818885-28-7) - Cayman Chem
ARV-825 is a hetero-bifunctional molecule that is composed of a BRD4 binding moiety joined to an E3 ligase cereblon binding moiety using proteolysis targeting chimera (PROTAC) …